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Pharmaceuticals and Biotechnology
Air Liquide in the value chain
  • API MANUFACTURING

  • DRUG FORMULATION, PACKAGING AND DISTRIBUTION

  • QUALITY CONTROL

Particle size reduction

Particle size reduction of APIs and excipients plays an important role in finished drug product performance and quality, with an impact on dissolution, bioavailability, content uniformity, and stability.

Cryogenic grinding, or cryo-grinding, involves cooling a material to low or very low temperatures with a cryogenic fluid (typically liquid nitrogen) in order to produce particles with a narrow size distribution. Cryogenic technology makes it possible to process soft or heat-sensitive products more efficiently and without the risk of thermal degradation. As materials become brittle, fine powders can be obtained easily and with a minimum expenditure of energy. Micronization, using gaseous nitrogen to create high particle velocity and high-energy impact between particles, can also be used to reduce and control particle size and improve product homogeneity. The resulting inert atmosphere further protects your products from oxidation, potential clumping due to atmospheric moisture, and reduces dust explosion risks.

Gases

We supply pure gases and gas mixtures in a range of volumes to meet your needs. Multi-compendial nitrogen meeting the monograph specifications of the three major pharmacopoeias (USP-NF, Ph. Eur., and JP) is available in certain locations.

Services

Our iDATAL web-based gas management telemetry system provides you with an accurate, easy-to-use and cost-effective means of tracking your cylinder gas usage. In addition, we provide gas handling safety expertise and a range of resources, including Certificates of Analysis (CoA) upon request.

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Resources